Receptor kinase-mediated plant sensing
Plant Signaling
As multicellular organisms, plants constantly perceive their environment and respond appropriately, which is required for their survival, as well as the coordination of their growth and development. In particular, we are focusing on cell surface-localised immune receptors, called pattern recognition receptors, that perceive microbe-derived or endogenous patterns to activate innate immune responses.
Plant pattern recognition receptors are receptor kinases or are part of receptor kinase complexes, and thus offer exquisite model systems to study the molecular basis of plant immunity, but also the mechanisms underlying the function, activation and regulation receptor kinase-mediated pathways in growth, development and responses to environmental stresses. In addition, we are interested in identifying and engineering immune receptors to improve disease resistance in crops.
Recent Publications
- The transcriptional landscape of Arabidopsis thaliana pattern-triggered immunity
Bjornson, Marta; Pimprikar, Priya; Nuernberger, Thorsten; Zipfel, Cyril
Nature Plants DOI: 10.1038/s41477-021-00874-5 MAR 2021 - A membrane-bound ankyrin repeat protein confers race-specific leaf rust disease resistance in wheat
Kolodziej, Markus C.; Singla, Jyoti; Sanchez-Martin, Javier; Zbinden, Helen; Simkova, Hana; Karafiatova, Miroslava; Dolezel, Jaroslav; Gronnier, Julien; Poretti, Manuel; Glauser, Gaetan; Zhu, Wangsheng; Koster, Philipp; Zipfel, Cyril; Wicker, Thomas; Krattinger, Simon; Keller, Beat
Nature Communications, DOI: 10.1038/s41467-020-20777-x FEB 11 2021 - A receptor-like protein mediates plant immune responses to herbivore-associated molecular patterns
Steinbrenner, Adam D.; Munoz-Amatriain, Maria; Chaparro, Antonio F.; Aguilar-Venegas, Jessica Montserrat; Lo, Sassoum; et al.
Proceedings Of The National Academy Of Sciences Of The United States Of America 117(49): 31510-31518 DOI: 10.1073/pnas.2018415117 DEC 8 2020 - Lumi-Map, a Real-Time Luciferase Bioluminescence Screen of Mutants Combined with MutMap, Reveals Arabidopsis Genes Involved in PAMP-Triggered Immunity
Kato, Hiroaki; Onai, Kiyoshi; Abe, Akira; Shimizu, Motoki; Takagi, Hiroki; et al.
Molecular Plant-microbe Interactions DOI: 10.1094/MPMI-05-20-0118-TA DEC 2020 - The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity
Thor, Kathrin; Jiang, Shushu; Michard, Erwan; George, Jeoffrey; Scherzer, Soenke; et al.
Nature DOI: 10.1038/s41586-020-2702-1, SEP 24 2020 - Chitin perception in plasmodesmata characterizes submembrane immune-signaling specificity in plants
Cheval, Cecilia; Samwald, Sebastian; Johnston, Matthew G.; de Keijzer, Jeroen; Breakspear, Andrew; et al.
Proceedings Of The National Academy Of Sciences Of The United States Of America, DOI: 10.1073/pnas.1907799117 APR 28 2020 - Update on Receptors and Signaling
Cheung, Alice Y.; Qu, Li-Jia; Russinova, Eugenia; Zhao, Yunde; Zipfel, Cyril
Plant Physiology DOI: 10.1104/pp.20.00275, APR 2020 - Carbonic anhydrases CA1 and CA4 function in atmospheric CO2-modulated disease resistance
Zhou, Yeling; Vroegop-Vos, Irene A.; Van Dijken, Anja J. H.; Van der Does, Dieuwertje; Zipfel, Cyril; et al.
Planta DOI: 10.1007/s00425-020-03370-w MAR 7 2020 - CrRLK1L receptor-like kinases HERK1 and ANJEA are female determinants of pollen tube reception
Galindo-Trigo, Sergio; Blanco-Tourinan, Noel; DeFalco, Tomas A.; Wells, Eloise S.; Gray, Julie E.; et al.
Embo Reports, 10.15252/embr.201948466, FEB 2020 - The fungal subtilase AsES elicits a PTI-like defence response in Arabidopsis thaliana plants independently of its enzymatic activity
del Pilar Caro, Maria; Holton, Nicholas; Conti, Gabriela; Laura Venturuzzi, Andrea; Gustavo Martinez-Zamora, Martin; et al.
Molecular Plant Pathology, DOI: 10.1111/mpp.12881 - TTL Proteins Scaffold Brassinosteroid Signaling Components at the Plasma Membrane to Optimize Signal Transduction in Arabidopsis
Amorim-Silva, V; Garcia-Moreno, A; Castillo, AG; Lakhssassi, N; del Valle, AE; Perez-Sancho, J; Li, YS; Pose, D; Perez-Rodriguez, J; Lin, J; Valpuesta, V; Borsani, O; Zipfel, C; Macho, AP; Botella, MA
PLANT CELL, 31 (8):1807-1828; 10.1105/tpc.19.00150 AUG 2019 - A Lotus japonicus cytoplasmic kinase connects Nod factor perception by the NFR5 LysM receptor to nodulation
Wong, JEMM; Nadzieja, M; Madsen, LH; Bucherl, CA; Dam, S; Sandal, NN; Couto, D; Derbyshire, P; Uldum-Berentsen, M; Schroeder, S; Schwammle, V; Nogueira, FCS; Asmussen, MH; Thirup, S; Radutoiu, S; Blaise, M; Andersen, KR; Menke, FLH; Zipfel, C; Stougaard, J
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116 (28):14339-14348; 10.1073/pnas.1815425116 JUL 9 2019 - Mechanisms of RALF peptide perception by a heterotypic receptor complex
Yu Xiao, Martin Stegmann, Zhifu Han, Thomas A. DeFalco, Katarzyna Parys, Li Xu, Youssef Belkhadir, Cyril Zipfel and Jijie Chai
Nature, 10 July 2019. DOI: 10.1038/s41586-019-1409-7 - Widely Conserved Attenuation of Plant MAMP-Induced Calcium Influx by Bacteria Depends on Multiple Virulence Factors and May Involve Desensitization of Host Pattern Recognition Receptors
Lammertz, M; Kuhn, H; Pfeilmeier, S; Malone, J; Zipfel, C; Kwaaitaal, M; Lin, NC; Kvitko, BH; Panstruga, R
MOLECULAR PLANT-MICROBE INTERACTIONS, 32 (5):608-621; 10.1094/MPMI-10-18-0291-R MAY 2019 - The grapevine (Vitis vinifera) LysM receptor kinases VvLYK1-1 and VvLYK1-2 mediate chitooligosaccharide-triggered immunity
Brule D; Villano C; Davies LJ; Trda L; Claverie J; Heloir MC; Chiltz A; Adrian M; Darblade B; Tornero P; Stransfeld L; Boutrot F; Zipfel C; Dry IB; Poinssot B
PLANT BIOTECHNOLOGY JOURNAL 17(4): 812-825 10.1111/pbi.13017 APR 2019 - Expression of the Arabidopsis thaliana immune receptor EFR in Medicago truncatula reduces infection by a root pathogenic bacterium, but not nitrogen-fixing rhizobial symbiosis
Pfeilmeier, S; George, J; Morel, A; Roy, S; Smoker, M; Stransfeld, L; Downie, JA; Peeters, N; Malone, JG; Zipfel, C
PLANT BIOTECHNOLOGY JOURNAL 17 (3): 569-579 10.1111/pbi.12999 MAR 2019 - Quantitative phosphoproteomic analysis reveals common regulatory mechanisms between effector- and PAMP-triggered immunity in plants
Kadota, Y; Liebrand, TWH; Goto, Y; Sklenar, J; Derbyshire, P; Menke, FLH; Torres, MA; Molina, A; Zipfel, C; Coaker, G; Shirasu, K
NEW PHYTOLOGIST 221 (4): 2160-2175 10.1111/nph.15523 MAR 2019 - Comparing Arabidopsis receptor kinase and receptor protein-mediated immune signaling reveals BIK1-dependent differences
Wan, WL; Zhang, LS; Pruitt, R; Zaidem, M; Brugman, R; Ma, XY; Krol, E; Perraki, A; Kilian, J; Grossmann, G; Stahl, M; Shan, LB; Zipfel, C; van Kan, JAL; Hedrich, R; Weigel, D; Gust, AA; Nurnberger, T
NEW PHYTOLOGIST 221(4): 2080-2095 DOI: 10.1111/nph.15497 MAR 2019 - Expression of the Arabidopsis thaliana immune receptor EFR in Medicago truncatula reduces infection by a root pathogenic bacterium, but not nitrogen-fixing rhizobial symbiosis
Pfeilmeier, S; George, J; Morel, A; Roy, S; Smoker, M; Stransfeld, L; Downie, JA; Peeters, N; Malone, JG; Zipfel, C
PLANT BIOTECHNOLOGY JOURNAL, 17 (3):569-579; 10.1111/pbi.12999 MAR 2019 - …

Prof. Dr. Cyril Zipfel
University of Zurich
Department of Plant and Microbial Biology
8008 Zurich
Tel: +41 44 63 48222
Publications
Research topics
- Plant innate immunity
- Plant receptor kinases
- Phosphorylation-based regulation of plant signaling
- Plasma membrane organization
- Cell wall integrity sensing
- Plant biotechnology
Interdisciplinary
- Protein-protein interactions
- Protein phosphorylation analysis
- Plant-bacteria interactions
- Bioimaging
- Signaling bioassays in immunity, growth and development
- Electrophysiology