Cell Wall Signaling and Remodeling

Different from animals, plants present a dynamic cell wall system that plays a key role in coordinating growth and development, and that serves as a link with the outside world. So, plants have developed a sophisticated communication network that allows them to constantly read their cell wall status and adapt it to the new developmental or environmental circumstances.

We are interested in understanding what are the signaling components that drive this communication system and allow for this dynamic behavior. In order to answer to that question, we use an integrated approach that combines structural biology and protein biochemistry with cell biology and genetics.

• Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2
  Rhodes, Jack; Yang, Huanjie; Moussu, Steven; Boutrot, Freddy; Santiago, Julia; Zipfel, Cyril
  Nature Communications 10.1038/s41467-021-20932-y  JAN 29 2021
• Arabidopsis natural variation in insect egg-induced cell death reveals a role for LECTIN RECEPTOR KINASE-I.1
  Groux, Raphael; Stahl, Elia; Gouhier-Darimont, Caroline; Kerdaffrec, Envel; Jimenez-Sandoval, Pedro; Santiago, Julia; Reymond, Philippe
  Plant Physiology  10.1093/plphys/kiaa022  Published: JAN 2021
• Mesophyll-derived sugars are positive regulators of light-driven stomatal opening
  Flutsch, Sabrina; Santelia, Diana
  New Phytologist   10.1111/nph.17322  Published: JUN 2021
• Computational prediction method to decipher receptor-glycoligand interactions in plant immunity
  del Hierro, Irene; Melida, Hugo; Broyart, Caroline; Santiago, Julia; Molina, Antonio
  Plant Journal 10.1111/tpj.15133  Published: MAR 2021
• In Vitro Analytical Approaches to Study Plant Ligand-Receptor Interactions
  Sandoval, Pedro Jimenez; Santiago, Julia
  Plant Physiology 182(4): 1697-1712 DOI: 10.1104/pp.19.01396  APR 2020
• Structural basis for recognition of RALF peptides by LRX proteins during pollen tube growth
  Moussu, Steven; Broyart, Caroline; Santos-Fernandez, Gorka; Augustin, Sebastian; Wehrle, Sarah; Grossniklaus, Ueli; Santiago, Julia
  Proceedings Of The National Academy Of Sciences Of The United States Of America  DOI: 10.1073/pnas.2000100117  Published: MAR 31 2020
• Structural biology of cell surface receptor-ligand interactions
  Moussu, Steven; Santiago, Julia
  Current Opinion In Plant Biology, 10.1016/j.pbi.2019.07.001, DEC 2019
• Crystal structures of two tandem malectin-like receptor kinases involved in plant reproduction
  Moussu, S; Augustin, S; Roman, AO; Broyart, C; Santiago, J
  ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 74 671-680; 10.1107/S205979831800774X 7 JUL 2018
• Mechanistic basis for the activation of plant membrane receptor kinases by SERK-family coreceptors
  Hohmann, U; Santiago, J; Nicolet, J; Olsson, V; Spiga, FM; Hothorn, LA; Butenko, MA; Hothorn, M
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115 (13):3488-3493; https://doi.org/10.1073/pnas.1714972115 MAR 27 2018
• Arabidopsis ILITHYIA protein is necessary for proper chloroplast biogenesis and root development independent of eIF2 alpha phosphorylation
  Faus, I.; Ninoles, R.; Kesari, V.; et al
  JOURNAL OF PLANT PHYSIOLOGY,10.1016/j.jplph.2018.04.003, MAY-JUN 2018
• Perception of root-active CLE peptides requires CORYNE function in the phloem vasculature 
  Hazak, Ora; Brandt, Benjamin; Cattaneo, Pietro; Santiago, J; Rodriguez-Villalon, A; Hothorn, M; Hardtke, CS
  EMBO REPORTS, 18 (8): 1367-1381 https://doi.org/10.15252/embr.201643535 AUG 2017
• How Do Plants Know When to Let Go? 
  Augustin, Sebastian; Santiago, Julia 
  CHIMIA, 71 (5): 310-310 https://doi.org/10.2533/chimia.2017.310 2017
• Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission
  Santiago, Julia; Brandt, Benjamin; Wildhagen, Mari; et al.
  ELIFE  5: e15075  10.7554/eLife.15075 APR 8 2016
• Crystal structures of the phosphorylated BRI1 kinase domain and implications for brassinosteroid signal initiation
  Bojar, Daniel; Martinez, Jacobo; Santiago, Julia; Rybin, V; Bayliss, R; Hothorn, M
  PLANT JOURNAL 78(1): 31-43 https://doi.org/10.1111/tpj.12445  APR 2014
• …

• Cell wall signaling and remodeling
• Receptor kinases
• Cell separation
• Plant membrane receptors

• Plant membrane signaling
• Plant cell wall signaling and remodeling
• Structural biology/ Dissecting signaling mechanisms
• Quantitative biochemistry
• Receptor-Ligand interactions
• Protein-protein interactions