Plant Biochemistry and Physiology

Our research focuses on plant metabolism, in particular the biochemistry and physiology behind vitamin biosynthesis and degradation and how these processes interact with other aspects of general primary plant metabolism. We also address aspects of stress physiology and how alteration of vitamin metabolism affects the response to abiotic stress responses. We use bacteria, yeast and the model plant Arabidopsis thaliana and a range of multi-disciplinary biological and chemical techniques as part of our research program.

• The coenzyme thiamine diphosphate displays a daily rhythm in the Arabidopsis nucleus
  Noordally, Zeenat B.; Trichtinger, Celso; Dalvit, Ivan; Hofmann, Manuel; Roux, Celine; et al.
  Communications Biology  DOI: 10.1038/s42003-020-0927-z Published: MAY 5 2020
• Clarification of the dispensability of PDX1.2 for Arabidopsis viability using CRISPR/Cas9
  Dell'Aglio, Elisa; Dalvit, Ivan; Loubery, Sylvain; Fitzpatrick, Teresa B.
  Bmc Plant Biology,  DOI: 10.1186/s12870-019-2071-9   Nov 2019
• Enhancement of vitamin B-6 levels in rice expressing Arabidopsis vitamin B-6 biosynthesis de novo genes
  Mangel, N; Fudge, JB; Li, KT; Wu, TY; Tohge, T; Fernie, AR; Szurek, B; Fitzpatrick, TB; Gruissem, W; Vanderschuren, H
  PLANT JOURNAL, 10.1111/tpj.14379 SEP 2019
• Appropriate Thiamin Pyrophosphate Levels Are Required for Acclimation to Changes in Photoperiod
  By: Rosado-Souza, L; Proost, S; Moulin, M; Bergmann, S; Bocobza, SE; Aharoni, A; Fitzpatrick, TB; Mutwil, M; Fernie, AR; Obata, T
  PLANT PHYSIOLOGY   Volume: 180   Issue: 1   Pages: 185-197   10.1104/pp.18.01346 MAY 2019
• Crystal structure of the pseudoenzyme PDX1.2 in complex with its cognate enzyme PDX1.3: a total eclipse
  Robinson, GC; Kaufmann, M; Roux, C; Martinez-Font, J; Hothorn, M; Thore, S; Fitzpatrick, TB
  ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 75 400-415; 10.1107/S2059798319002912 4 APR 2019
• The Pseudoenzyme PDX1.2 Sustains Vitamin B-6 Biosynthesis as a Function of Heat Stress 
  Dell'Aglio, Elisa; Boycheva, Svetlana; Fitzpatrick, Teresa B. 
  PLANT PHYSIOLOGY, 174 (4): 2098-2112 10.1104/pp.17.00531  AUG 2017
• Vitamin B-1 diversity and characterization of biosynthesis genes in cassava 
  Mangel, Nathalie; Fudge, Jared B.; Fitzpatrick, Teresa B.; Gruissem, Wilhelm; Vanderschuren, Herve
  JOURNAL OF EXPERIMENTAL BOTANY, 68 (13): 3351-3363  10.1093/jxb/erx196 JUN 15 2017
• Editorial overview: Biofortification of crops: achievements, future challenges, socio-economic, health and ethical aspects 
  Van Der Straeten, Dominique; Fitzpatrick, Teresa B.; De Steur, Hans 
  CURRENT OPINION IN BIOTECHNOLOGY, 44: VII-X  10.1016/j.copbio.2017.03.007 APR 2017
• Rationalising vitamin B-6 biofortification in crop plants 
  Fudge, Jared; Mangel, Nathalie; Gruissem, Wilhelm; Vanderschuren, Herve; Fitzpatrick, Teresa B
  CURRENT OPINION IN BIOTECHNOLOGY, 44: 130-137 APR 2017 https://doi.org/10.1016/j.copbio.2016.12.004
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• Vitamin metabolism
• Abiotic stress
• Transport processes
• Enzyme mechanisms
• Protein chemistry

• Plant physiology and biochemistry
• Genetics
• Genomics, proteomics and metabolomics
• Cell biology