Plant Biochemistry and Physiology

Our research focuses on plant metabolism, in particular the biochemistry and physiology behind vitamin biosynthesis and degradation and how these processes interact with other aspects of general primary plant metabolism. We also address aspects of stress physiology and how alteration of vitamin metabolism affects the response to abiotic stress responses. We use bacteria, yeast and the model plant Arabidopsis thaliana and a range of multi-disciplinary biological and chemical techniques as part of our research program.

• Natural Variation in Vitamin B-1 and Vitamin B-6 Contents in Rice Germplasm
  Mangel, Nathalie; Fudge, Jared B.; Gruissem, Wilhelm; Fitzpatrick, Teresa B.; Vanderschuren, Herve
  Frontiers In Plant Science  10.3389/fpls.2022.856880  APR 4 2022
• Nitric oxide regulation of plant metabolism
  Gupta, Kapuganti Jagadis; Kaladhar, Vemula Chandra; Fitzpatrick, Teresa B.; Fernie, Alisdair R.; Moller, Ian Max; et al.
  Molecular Plant  10.1016/j.molp.2021.12.012  FEB 7 2022
• Loss of a pyridoxal-phosphate phosphatase rescues Arabidopsis lacking an endoplasmic reticulum ATP carrier
  Altensell, Jacqueline; Wartenberg, Ruth; Haferkamp, Ilka; Hassler, Sebastian; Scherer, Vanessa; et al.
  Plant Physiology  10.1093/plphys/kiac048  MAY 3 2022
• Phosphorylated B-6 vitamer deficiency in SALT OVERLY SENSITIVE 4 mutants compromises shoot and root development
  Gorelova, Vera; Colinas, Maite; Dell'Aglio, Elisa; Flis, Paulina; Salt, David E.; et al.
  Plant Physiology  10.1093/plphys/kiab475  JAN 2022
• A novel panel of yeast assays for the assessment of thiamin and its biosynthetic intermediates in plant tissues
  Strobbe, Simon; Verstraete, Jana; Fitzpatrick, Teresa B.; Faustino, Maria; Lourenco, Tiago F.; et al.
  New Phytologist  10.1111/nph.17974  APR 2022
• Of clocks and coenzymes in plants: intimately connected cycles guiding central metabolism?
  Fitzpatrick, Teresa B.; Noordally, Zeenat
  New Phytologist, 10.1111/nph.17127  APR 2021
• The importance of thiamine (vitamin B-1) in plant health: From crop yield to biofortification
  Fitzpatrick, Teresa B.; Chapman, Lottie M.
  Journal Of Biological Chemistry,  10.1074/jbc.REV120.010918 AUG 21 2020
• On the nature of thiamine triphosphate in Arabidopsis
  Hofmann, Manuel; Loubery, Sylvain; Fitzpatrick, Teresa B.
  Plant Direct, 10.1002/pld3.258   AUG 2020
• The coenzyme thiamine diphosphate displays a daily rhythm in the Arabidopsis nucleus
  Noordally, Zeenat B.; Trichtinger, Celso; Dalvit, Ivan; Hofmann, Manuel; Roux, Celine; et al.
  Communications Biology  DOI: 10.1038/s42003-020-0927-z Published: MAY 5 2020
• Clarification of the dispensability of PDX1.2 for Arabidopsis viability using CRISPR/Cas9
  Dell'Aglio, Elisa; Dalvit, Ivan; Loubery, Sylvain; Fitzpatrick, Teresa B.
  Bmc Plant Biology,  DOI: 10.1186/s12870-019-2071-9   Nov 2019
• Enhancement of vitamin B-6 levels in rice expressing Arabidopsis vitamin B-6 biosynthesis de novo genes
  Mangel, N; Fudge, JB; Li, KT; Wu, TY; Tohge, T; Fernie, AR; Szurek, B; Fitzpatrick, TB; Gruissem, W; Vanderschuren, H
  PLANT JOURNAL, 10.1111/tpj.14379 SEP 2019
• Appropriate Thiamin Pyrophosphate Levels Are Required for Acclimation to Changes in Photoperiod
  By: Rosado-Souza, L; Proost, S; Moulin, M; Bergmann, S; Bocobza, SE; Aharoni, A; Fitzpatrick, TB; Mutwil, M; Fernie, AR; Obata, T
  PLANT PHYSIOLOGY   Volume: 180   Issue: 1   Pages: 185-197   10.1104/pp.18.01346 MAY 2019
• Crystal structure of the pseudoenzyme PDX1.2 in complex with its cognate enzyme PDX1.3: a total eclipse
  Robinson, GC; Kaufmann, M; Roux, C; Martinez-Font, J; Hothorn, M; Thore, S; Fitzpatrick, TB
  ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 75 400-415; 10.1107/S2059798319002912 4 APR 2019
• The Pseudoenzyme PDX1.2 Sustains Vitamin B-6 Biosynthesis as a Function of Heat Stress 
  Dell'Aglio, Elisa; Boycheva, Svetlana; Fitzpatrick, Teresa B. 
  PLANT PHYSIOLOGY, 174 (4): 2098-2112 10.1104/pp.17.00531  AUG 2017
• Vitamin B-1 diversity and characterization of biosynthesis genes in cassava 
  Mangel, Nathalie; Fudge, Jared B.; Fitzpatrick, Teresa B.; Gruissem, Wilhelm; Vanderschuren, Herve
  JOURNAL OF EXPERIMENTAL BOTANY, 68 (13): 3351-3363  10.1093/jxb/erx196 JUN 15 2017
• …

• Vitamin metabolism
• Abiotic stress
• Transport processes
• Enzyme mechanisms
• Protein chemistry

• Plant physiology and biochemistry
• Genetics
• Genomics, proteomics and metabolomics
• Cell biology