Plant adaptation and speciation in the face of gene flow
Speciation and adaptive divergence often include periods of gene flow. Whether this gene flow occurs prior, during, or after the evolution of reproductive isolation, and what consequences gene flow has on the architecture of traits under divergent selection are fundamental questions that remain largely unanswered.
While we now have unprecedented amounts of genome scale data, there is a lack of statistical approaches to make robust inference from these data. To fill this gap, we combine mathematical modelling and population genetic theory to devise statistical procedures for the joint inference of demography and selection. Applying these approaches to genome-wide sequence and recombination data, we ask how selection modifies gene flow in speciation, what genes act as barriers to gene flow, and how deleterious mutations accumulate in populations as a function of demographic history. We currently use Mimulus and wild tomatoes (Solanum section Lycopersicon) as our main study systems.
- Background selection and biased gene conversion affect more than 95% of the human genome and bias demographic inferences.
Poyet F, Aeschbacher S, Thiéry A, Excoffier L (2018).
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- Population-genomic inference of the strength and timing of selection against gene flow.
Aeschbacher S, Selby JP, Willis JH, Coop G (2017).
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- The strength of selection against Neanderthal introgression.
Jurić I, Aeschbacher S, Coop G (2016).
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- The evolution of genomic islands by increased establishment probability of linked alleles.
Yeaman S, Aeschbacher S, Bürger R (2016).
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- The effect of linkage on establishment and survival of locally beneficial mutations.
Aeschbacher S, Bürger R (2014).
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- Approximate Bayesian computation for modular inference problems with many parameters: the example of migration rates.
Aeschbacher S, Futschik A, Beaumont MA (2013).
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- A novel approach for choosing summary statistics in approximate Bayesian computation.
Aeschbacher S, Beaumont MA, Futschik S (2012).
Genetics 192 (3): 1027–1047. DOI: 10.1534/genetics.112.143164
- Inferring the timing and strength of gene flow and selection
- Understanding the genetic basis of adaptation and speciation
- Quantifying the impact of demography on natural selection
- Mathematics and biology
- Theoretical and applied population genetics